Week 16 of the 2025 NFL season ends tonight with a Monday Night Football game between the San Francisco 49ers and Indianapolis Colts. The Philadelphia Eagles’ chances of getting the No. 1 seed are incredibly slim (like, 0.1% chance slim) but the Birds will remain mathematically alive for a first-round bye if the 49ers lose […]
From Bleeding Green Nation
| 2 months ago
| 1 read
Okay, so Philip Rivers almost had a dream comeback after ending his five-year retirement to play for the Indianapolis Colts. The Seattle Seahawks thwarted Rivers with an 18-16 victory thanks to six Jason Myers field goals. Philip Rivers is 4-0 against the San Francisco 49ers. A win for the Colts at home on Monday Night […]
From Field Gulls
| 2 months ago
| 0 reads
Week 16 of the NFL season winds down this evening with the San Francisco 49ers traveling cross-country to take on the Indianapolis Colts. The 49ers enter this game having already secured a playoff spot and have an opportunity to move within one game of the AFC West’s current leaders, the Seattle Seahawks. The Colts were […]
From The Phinsider
| 2 months ago
| 1 read
Week 16 comes to a close with a “Monday Night Football” matchup featuring the San Francisco 49ers (10-4) and the Indianapolis Colts (8-6). The 49ers have clinched a playoff berth in the NFC Playoffs—the Detroit Lions can only hope to tie their record, and San Francisco holds the tie-breaker, so they’re in—but they’re still fully […]
From Pride Of Detroit
| 2 months ago
| 1 read
Week 16 concludes this evening, with the Colts taking on the 49ers on Monday Night Football.
How to Watch Monday Night Football: Colts vs. 49ers
TV: ABC
Streaming: NFL+
Radio: Westwood One
Kickoff Time: 7:15 PM CT
Site: Lucas Oil Stadium, Indianapolis, IN.
Referee: Ron Torbert
Odds : 49ers -5.5, O/U 45.5 ( via DraftKings Sportsbook )
Kevin Ng-Imagn Images
Colts Projected Starters
Offense
QB – Philip Rivers
RB – Jonath...
From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| 2 months ago
| 0 reads
The Seattle Seahawks entered Week 16 in second place in the NFC West and as the No. 5 seed and exited with the division lead and control of the coveted No. 1 seed. While the easiest way for the Seahawks to confirm their home-field advantage throughout the playoffs is to win their remaining two games, […]
From Field Gulls
| 2 months ago
| 1 read
Monday night brings some solid sports action, and a bet365 bonus code can be used for any matchup. This gets you $150 in bonus bets for games like the 49ers taking on the Colts.
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From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| 2 months ago
| 0 reads
The Indianapolis Colts (8-6) host the San Francisco 49ers (10-4) on primetime (8:15 PM EST) trying to keep their late season playoff hopes alive. Having lost 5 of their last 6 games, it’s desperation time in Indy. Entering the evening, the Colts average the league’s 6th most points (28.0 avg. ppg.) and surrender its 13th […]
From Stampede Blue
| 2 months ago
| 3 reads
Monday Night Football brings an interconference matchup that puts the San Francisco 49ers on the road against the Indianapolis Colts. This game matters for playoff positioning and momentum, and the betting market reflects a competitive but clearly defined matchup. You are looking at a spread under a touchdown, a mid-range total, and moneylines that suggest one team holds the edge but still faces risk away from home.
Below is a full betting-focused preview designed to help you evaluate the...
From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| 2 months ago
| 0 reads
The San Francisco 49ers are in the playoffs. Week 16 has been kind to them. There are a couple of outcomes from a seeding perspective, based on how Monday night against the Indianapolis Colts goes. Oddsmakers believe the 49ers are nearly a touchdown better than the Colts. We will see if it plays out that […]
From Niners Nation
| 2 months ago
| 1 read
Monday Night Football delivers another exciting game with the 49ers vs Colts battling for playoff positioning. Both teams boast good lineups that offer numerous NFL DFS options on BN Fantasy . The 49ers have one of the league’s most dangerous players in Christian McCaffrey. Meanwhile, the Colts will lean on their own star runner, Jonathan Taylor with Philip Rivers making his 2nd start.
To make the night more exciting, BN Fantasy has a couple of awesome promos available for new users. Firs...
From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| 2 months ago
| 2 reads
Indianapolis, IN — The Indianapolis Colts have received a big-time reinforcement ahead of their Monday Night Football matchup against the San Francisco 49ers. Star defensive tackle DeForest Buckner (neck) has officially been activated from the injured reserve list after missing the last five games, a fitting return to the limelight as this is Indy’s first […]
From Stampede Blue
| 2 months ago
| 7 reads
With the San Francisco 49ers winning their last four games against what may be the easiest stretch of their schedule, they turn around to begin the toughest stretch of their schedule with a Monday night tilt against the Indianapolis Colts. A few weeks ago, this game against Indianapolis was trending towards being a matchup between […]
From Niners Nation
| 2 months ago
| 1 read
The wildest storyline of the NFL season continues tonight as 44-year-old quarterback Philip Rivers will start at quarterback for the second straight week for the Colts. Check out his passing props and odds for tonight’s Monday Night Football game between the 49ers and Colts.
$250 deposit bonus for NFL pick’em contests!
Philip Rivers Passing Props
(Rivers played his first game since 2020 last week. Photo: Kevin Ng-Imagn Images)
The Colts shocked the world last week when they...
From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| 2 months ago
| 0 reads
New users can score a Kalshi promo code to make trades on prediction markets like Monday Night Football’s matchup between the 49ers and Colts. Here is how to get your $10 bonus.
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Use the Kalshi promo code BNATION to earn a $10 bonus after making $100 in trades.
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From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| 2 months ago
| 0 reads
The San Francisco 49ers travel to Naptown to take on the Indianapolis Colts. One team is surging and playing for the No. 1 seed, while the other is fighting for its playoff hopes. The Niners are going to get the Colts’ best punch on Monday night. It’s a game Indy needs, so expect Shane Steichen […]
From Niners Nation
| 2 months ago
| 1 read
The Jacksonville Jaguars (11-4) will fly from the Rocky Mountains to the Midwest to face the Indianapolis Colts (8-6 at the time of this writing) at 1:00 p.m. EST on Sunday, Dec. 28. According to FanDuel Sportsbook, the Jaguars are 6.5-point favorites and the total is set at 45.5 points. The Colts play tonight on […]
From Big Cat Country
| 2 months ago
| 0 reads
The Los Angeles Chargers are coming off a big win against Dak Prescott and the Dallas Cowboys in Week 16, getting one step closer to a playoff berth. The Chargers can officially clinch a playoff spot if the San Francisco 49ers beat the Indianapolis Colts on Monday Night Football, but they will also do so […]
From Bolts From The Blue
| 2 months ago
| 1 read
New users can score a BetMGM bonus code for a $1,500 offer, including games like the 49ers taking on the Colts. Here is what you need to do.
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Use the BetMGM bonus code BLEACHNEWS for a $1,500 first bet offer. Your first wager is covered by bonus bets if you lose.
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From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| 2 months ago
| 0 reads
At 7-1, the Indianapolis Colts were in firm control, not only of the AFC South but of the entire AFC. A tie breaker win over the Denver Broncos provided that much more room to breathe. Things were smooth sailing until they weren’t. With four straight losses and five out of six dropped, the Colts no […]
From Stampede Blue
| 2 months ago
| 4 reads
49ers lock up a playoff berth in wake of Lions’ loss to Pittsburgh (paywall)“The 49ers secured a playoff berth on Sunday when the Lions lost to the Steelers, 29-24, assuring San Francisco of reaching the postseason after a one-season absence.” Five 49ers players to keep an eye on in prime-time Week 16 game vs. Colts“Although […]
From Niners Nation
| 3 months ago
| 2 reads
The Indianapolis Colts announced on Sunday that starting left tackle Bernhard Raimann (elbow) has been downgraded from questionable to out for Monday Night football’s home game against the San Francisco 49ers. Raimann was able to practice on a limited basis on Saturday for the first time all week, with an arm brace on his injured […]
From Stampede Blue
| 3 months ago
| 1 read
The San Francisco 49ers (10-4) bring a four-game winning streak into a matchup against the Indianapolis Colts (8-6) on Monday, December 22, 2025 at Lucas Oil Stadium. San Francisco is a 5.5-point favorite in the contest. The over/under is set at 46 points for the outing.
Ready to watch the game? Sign up for Fubo to watch the NFL, live sports and entertainment without cable!
How to watch 49ers vs. Colts: TV channel & live stream
TV channel: ESPN
49ers Insights
The 49ers’ offen...
From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| 3 months ago
| 0 reads
The San Francisco 49ers (10-4) will be monitoring three players on their injury report going into a Monday, Dec. 22 game against the Indianapolis Colts (8-6) at Lucas Oil Stadium, due to start at 8:15 p.m. ET. The Colts currently have five players listed on their report.
How to Watch 49ers vs. Colts
Game date: Monday, December 22, 2025
Time: 8:15 p.m. ET
Venue: Lucas Oil Stadium
Location: Indianapolis, Indiana
TV: ESPN
Sign up for Fubo to watch the NFL, live sports and entert...
From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| 3 months ago
| 0 reads
The Indianapolis Colts (8-6) will have their eyes set on rebounding from their four-game losing streak when they take on the San Francisco 49ers (10-4) at Lucas Oil Stadium on Monday, December 22, 2025.
49ers vs. Colts Odds
Point Spread
The spread for this matchup is set at 5.5 points, with sportsbooks listing the 49ers as the favorites.
Moneyline
As for the moneyline, the 49ers have -258 odds to pick up the win, while the Colts are listed at +209 to claim victory.
Over/Under
Fin...
From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| 3 months ago
| 7 reads