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Brock Purdy’s 5 touchdowns lead the 49ers to a blowout win over the Colts

The Indianapolis Colts only attempted two passes beyond 20 yards against the Seattle Seahawks in Week 15. On the first play from scrimmage against the San Francisco 49ers, Philip Rivers “let it fly.” His first throw traveled 45 yards. That would be the last mistake Rivers made on the drive. Tatum Bethune was on Jonathan […]

Chargers playoff picture: Los Angeles clinches playoff spot with Colts loss on ‘Monday Night Football’

The Los Angeles Chargers clinched a playoff spot on Monday without even playing in the game. The Indianapolis Colts lost to fellow playoff hopefuls in the San Francisco 49ers. The game isin Indianapolis featured former Chargers quarterback Phillip Rivers as Indy’s starting QB. Updated AFC standings How the Chargers clinched a playoff spot Now that […]

Philip Rivers took the 49ers to school on Colts opening drive

Indianapolis, IN — Clinical, surgical, teach tape: these are just a few words that accurately describe Philip Rivers’s opening drive in primetime against the San Francisco 49ers. Starting center Tanor Bortolini went down early with a concussion, making it the Colts’ third consecutive week in which a starting offensive lineman left the game with injury, […]

49ers can knock Rams down a peg tonight

If the San Francisco 49ers beat the Indianapolis Colts on Monday, the Los Angeles Rams will slip from the 5 seed to the 6 seed in the NFC playoff picture. It’s a remarkable turnaround from where these teams were at going into their Week 5 matchup — an overtime win by the 49ers — and […]

49ers vs. Colts: Monday Night Football Game Discussion

The Indianapolis Colts host the San Francisco 49ers in Indy. These teams are on vastly different trajectories, as the Niners are on a four-game winning streak and Indy is on a four-game losing streak. Will San Francisco make it five-straight? Can Indy avoid five-straight? Let’s tune in to find out! San Francisco 49ers at Indianapolis Colts Lucas […]

49ers-Colts game thread: Tonight will come down to red zone execution

For all of the talk about how the San Francisco 49ers still need to win. And despite playing a quarterback who is projected to throw for 159 yards tonight, this will not be an easy game. The Indianapolis Colts have several weapons at Philip Rivers’ disposal, and the best one is at running back. Jonathan […]

Buffalo Bills fan discussion: Playoff picture chat with Indianapolis Colts on ‘Monday Night Football’

After tonight, there’s just two weeks left on the 2025 NFL regular-season schedule. To wrap up Week 16, we get a Monday Night Football matchup between the Indianapolis Colts and San Francisco 49ers that should hold everyone’s interests. If you’re looking for Buffalo Bills-related playoff rooting interests, the task is simple: With a Colts loss, […]

49ers vs. Colts: Monday Night Football

Week 16 of the 2025 NFL season ends tonight with a Monday Night Football game between the San Francisco 49ers and Indianapolis Colts. The Philadelphia Eagles’ chances of getting the No. 1 seed are incredibly slim (like, 0.1% chance slim) but the Birds will remain mathematically alive for a first-round bye if the 49ers lose […]

49ers vs. Colts live discussion: Philip Rivers can help the Seahawks

Okay, so Philip Rivers almost had a dream comeback after ending his five-year retirement to play for the Indianapolis Colts. The Seattle Seahawks thwarted Rivers with an 18-16 victory thanks to six Jason Myers field goals. Philip Rivers is 4-0 against the San Francisco 49ers. A win for the Colts at home on Monday Night […]

49ers at Colts, Week 16 MNF fan discussion

Week 16 comes to a close with a “Monday Night Football” matchup featuring the San Francisco 49ers (10-4) and the Indianapolis Colts (8-6). The 49ers have clinched a playoff berth in the NFC Playoffs—the Detroit Lions can only hope to tie their record, and San Francisco holds the tie-breaker, so they’re in—but they’re still fully […]

Monday Night Football: Colts vs. 49ers – Lineups, Broadcast Info, Game Thread, More

Week 16 concludes this evening, with the Colts taking on the 49ers on Monday Night Football. How to Watch Monday Night Football: Colts vs. 49ers TV: ABC Streaming: NFL+ Radio: Westwood One Kickoff Time: 7:15 PM CT Site: Lucas Oil Stadium, Indianapolis, IN. Referee: Ron Torbert Odds : 49ers -5.5, O/U 45.5 ( via DraftKings Sportsbook ) Kevin Ng-Imagn Images Colts Projected Starters Offense QB  – Philip Rivers RB  – Jonath...

bet365 Bonus Code BNATION Earns $150 for Monday Night Football and More

Monday night brings some solid sports action, and a bet365 bonus code can be used for any matchup. This gets you $150 in bonus bets for games like the 49ers taking on the Colts. bet365 Bonus Code BNATION New users can register with the bonus code BNATION to score the bonus. Sign up with BNATION on bet365. 21+ to wager (18+ in Kentucky). Geolocation confirms if you can bet in your state. Make a deposit. Place a $5 bet… First wager must be -500 od...

Can Jonathan Taylor get back to form against the 49ers?

It wasn’t so long ago that Jonathan Taylor was the front runner for Offensive Player of the Year and a sleeper pick for MVP despite being a Running Back. But the past month has done him no favors in his candidacy for either award. In his 4 games since the Bye Week, Taylor’s stats have […]

Where to Watch: 49ers at Colts for MNF

The Indianapolis Colts (8-6) host the San Francisco 49ers (10-4) on primetime (8:15 PM EST) trying to keep their late season playoff hopes alive. Having lost 5 of their last 6 games, it’s desperation time in Indy. Entering the evening, the Colts average the league’s 6th most points (28.0 avg. ppg.) and surrender its 13th […]

49ers vs Colts Spread, Game Odds, and More for Monday Night Football

Monday Night Football brings an interconference matchup that puts the San Francisco 49ers on the road against the Indianapolis Colts. This game matters for playoff positioning and momentum, and the betting market reflects a competitive but clearly defined matchup. You are looking at a spread under a touchdown, a mid-range total, and moneylines that suggest one team holds the edge but still faces risk away from home. Below is a full betting-focused preview designed to help you evaluate the...

49ers activate Yetur Gross-Matos from the Injured Reserve; also make 2 practice squad moves

The San Francisco 49ers activated Yetur Gross-Matos from the Injured Reserve list for tonight’s game against the Indianapolis Colts. We have not seen Gross-Matos in action since Week 5. The 49ers couldn’t have been more patient with Gross-Matos, as he recovered from a hamstring injury. What will Gross-Matos’s availability look like tonight? He’s played 17, […]

NFL DFS Picks for 49ers vs Colts Including Christian McCaffrey & Jonathan Taylor on BN Fantasy for MNF Week 16

Monday Night Football delivers another exciting game with the 49ers vs Colts battling for playoff positioning. Both teams boast good lineups that offer numerous NFL DFS options on BN Fantasy . The 49ers have one of the league’s most dangerous players in Christian McCaffrey. Meanwhile, the Colts will lean on their own star runner, Jonathan Taylor with Philip Rivers making his 2nd start. To make the night more exciting, BN Fantasy has a couple of awesome promos available for new users. Firs...