The Indianapolis Colts only attempted two passes beyond 20 yards against the Seattle Seahawks in Week 15. On the first play from scrimmage against the San Francisco 49ers, Philip Rivers “let it fly.” His first throw traveled 45 yards. That would be the last mistake Rivers made on the drive. Tatum Bethune was on Jonathan […]
The Los Angeles Chargers clinched a playoff spot on Monday without even playing in the game. The Indianapolis Colts lost to fellow playoff hopefuls in the San Francisco 49ers. The game isin Indianapolis featured former Chargers quarterback Phillip Rivers as Indy’s starting QB. Updated AFC standings How the Chargers clinched a playoff spot Now that […]
The Jacksonville Jaguars clinched their playoff spot during Monday Night Football when the Indianapolis Colts lost to the San Francisco 49ers. Jaguars players and fans were surely be tuned in to watch their division rival and see if they can punch their postseason pass. Updated AFC standings How the Jaguars clinched a playoff spot Now […]
Indianapolis, IN — Clinical, surgical, teach tape: these are just a few words that accurately describe Philip Rivers’s opening drive in primetime against the San Francisco 49ers. Starting center Tanor Bortolini went down early with a concussion, making it the Colts’ third consecutive week in which a starting offensive lineman left the game with injury, […]
If the San Francisco 49ers beat the Indianapolis Colts on Monday, the Los Angeles Rams will slip from the 5 seed to the 6 seed in the NFC playoff picture. It’s a remarkable turnaround from where these teams were at going into their Week 5 matchup — an overtime win by the 49ers — and […]
The Indianapolis Colts host the San Francisco 49ers in Indy. These teams are on vastly different trajectories, as the Niners are on a four-game winning streak and Indy is on a four-game losing streak. Will San Francisco make it five-straight? Can Indy avoid five-straight? Let’s tune in to find out! San Francisco 49ers at Indianapolis Colts Lucas […]
For all of the talk about how the San Francisco 49ers still need to win. And despite playing a quarterback who is projected to throw for 159 yards tonight, this will not be an easy game. The Indianapolis Colts have several weapons at Philip Rivers’ disposal, and the best one is at running back. Jonathan […]
Closing out Week 16 with the 49ers and the Colts. This is an open thread for game chat.
After tonight, there’s just two weeks left on the 2025 NFL regular-season schedule. To wrap up Week 16, we get a Monday Night Football matchup between the Indianapolis Colts and San Francisco 49ers that should hold everyone’s interests. If you’re looking for Buffalo Bills-related playoff rooting interests, the task is simple: With a Colts loss, […]
The 10-4 San Francisco 49ers have a chance to inch even closer to winning the NFC West as they travel to Indianapolis to take on the reeling 8-6 Colts. This could be a good one, and if not, you’ll still get to watch Philip Rivers play football in the big 2025. As always, let us […]
Week 16 of the 2025 NFL season ends tonight with a Monday Night Football game between the San Francisco 49ers and Indianapolis Colts. The Philadelphia Eagles’ chances of getting the No. 1 seed are incredibly slim (like, 0.1% chance slim) but the Birds will remain mathematically alive for a first-round bye if the 49ers lose […]
Okay, so Philip Rivers almost had a dream comeback after ending his five-year retirement to play for the Indianapolis Colts. The Seattle Seahawks thwarted Rivers with an 18-16 victory thanks to six Jason Myers field goals. Philip Rivers is 4-0 against the San Francisco 49ers. A win for the Colts at home on Monday Night […]
Week 16 of the NFL season winds down this evening with the San Francisco 49ers traveling cross-country to take on the Indianapolis Colts. The 49ers enter this game having already secured a playoff spot and have an opportunity to move within one game of the AFC West’s current leaders, the Seattle Seahawks. The Colts were […]
Week 16 comes to a close with a “Monday Night Football” matchup featuring the San Francisco 49ers (10-4) and the Indianapolis Colts (8-6). The 49ers have clinched a playoff berth in the NFC Playoffs—the Detroit Lions can only hope to tie their record, and San Francisco holds the tie-breaker, so they’re in—but they’re still fully […]
The San Francisco 49ers’ inactive list is out: RB Isaac GuerendoWR Ricky PearsallDL Robert BealDT Kevin GivensLB Curtis RobinsonCB Renardo GreenCB Chase Lucas This will be the first game Guerendo hasn’t played in all season. He’s been the primary gunner on special teams all season. Last week was the first time Guerendo didn’t play a […]
Week 16 concludes this evening, with the Colts taking on the 49ers on Monday Night Football.
How to Watch Monday Night Football: Colts vs. 49ers
TV: ABC
Streaming: NFL+
Radio: Westwood One
Kickoff Time: 7:15 PM CT
Site: Lucas Oil Stadium, Indianapolis, IN.
Referee: Ron Torbert
Odds : 49ers -5.5, O/U 45.5 ( via DraftKings Sportsbook )
Kevin Ng-Imagn Images
Colts Projected Starters
Offense
QB – Philip Rivers
RB – Jonath...
The Seattle Seahawks entered Week 16 in second place in the NFC West and as the No. 5 seed and exited with the division lead and control of the coveted No. 1 seed. While the easiest way for the Seahawks to confirm their home-field advantage throughout the playoffs is to win their remaining two games, […]
Monday night brings some solid sports action, and a bet365 bonus code can be used for any matchup. This gets you $150 in bonus bets for games like the 49ers taking on the Colts.
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ESPN’s Nick Wagoner sat down with San Francisco 49ers defensive coordinator Robert Saleh, who reiterated some of his previous thoughts about becoming a head coach again. According to ESPN’s Jeremy Fowler’s league sources, Saleh is expected to be a fixture during this upcoming hiring cycle due to his work this year with the 49ers and […]
It wasn’t so long ago that Jonathan Taylor was the front runner for Offensive Player of the Year and a sleeper pick for MVP despite being a Running Back. But the past month has done him no favors in his candidacy for either award. In his 4 games since the Bye Week, Taylor’s stats have […]
The Indianapolis Colts (8-6) host the San Francisco 49ers (10-4) on primetime (8:15 PM EST) trying to keep their late season playoff hopes alive. Having lost 5 of their last 6 games, it’s desperation time in Indy. Entering the evening, the Colts average the league’s 6th most points (28.0 avg. ppg.) and surrender its 13th […]
Monday Night Football brings an interconference matchup that puts the San Francisco 49ers on the road against the Indianapolis Colts. This game matters for playoff positioning and momentum, and the betting market reflects a competitive but clearly defined matchup. You are looking at a spread under a touchdown, a mid-range total, and moneylines that suggest one team holds the edge but still faces risk away from home.
Below is a full betting-focused preview designed to help you evaluate the...
The San Francisco 49ers are in the playoffs. Week 16 has been kind to them. There are a couple of outcomes from a seeding perspective, based on how Monday night against the Indianapolis Colts goes. Oddsmakers believe the 49ers are nearly a touchdown better than the Colts. We will see if it plays out that […]
The San Francisco 49ers activated Yetur Gross-Matos from the Injured Reserve list for tonight’s game against the Indianapolis Colts. We have not seen Gross-Matos in action since Week 5. The 49ers couldn’t have been more patient with Gross-Matos, as he recovered from a hamstring injury. What will Gross-Matos’s availability look like tonight? He’s played 17, […]
Monday Night Football delivers another exciting game with the 49ers vs Colts battling for playoff positioning. Both teams boast good lineups that offer numerous NFL DFS options on BN Fantasy . The 49ers have one of the league’s most dangerous players in Christian McCaffrey. Meanwhile, the Colts will lean on their own star runner, Jonathan Taylor with Philip Rivers making his 2nd start.
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