While the 49ers’ Week 15 win over the Tennessee Titans never looked in doubt, the dominant nature of the victory did not mask a troubling performance from the San Francisco defense, which will need to bounce back if Kyle Shanahan’s playoff-bound Niners are to take another step towards the one seed in the NFC by […]
From Niners Nation
| 30 days ago
| 1 read
New users can score a BetMGM bonus code for a $1,500 offer, including games like the 49ers taking on the Colts. Here is what you need to do.
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Use the BetMGM bonus code BLEACHNEWS for a $1,500 first bet offer. Your first wager is covered by bonus bets if you lose.
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If you don...
From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| 30 days ago
| 0 reads
49ers lock up a playoff berth in wake of Lions’ loss to Pittsburgh (paywall)“The 49ers secured a playoff berth on Sunday when the Lions lost to the Steelers, 29-24, assuring San Francisco of reaching the postseason after a one-season absence.” Five 49ers players to keep an eye on in prime-time Week 16 game vs. Colts“Although […]
From Niners Nation
| 30 days ago
| 2 reads
The Indianapolis Colts announced on Sunday that starting left tackle Bernhard Raimann (elbow) has been downgraded from questionable to out for Monday Night football’s home game against the San Francisco 49ers. Raimann was able to practice on a limited basis on Saturday for the first time all week, with an arm brace on his injured […]
From Stampede Blue
| about 1 month ago
| 1 read
The (11-4) Chicago Bears get a cold-weather respite for their next game, but they have to fly out west to do so. On Sunday night, December 28, the Bears will be at Levi’s Stadium to take on the (10-4) San Francisco 49ers. The early weather look-ahead calls for a high of 51 and a low […]
From Windy City Gridiron
| about 1 month ago
| 0 reads
The San Francisco 49ers (10-4) bring a four-game winning streak into a matchup against the Indianapolis Colts (8-6) on Monday, December 22, 2025 at Lucas Oil Stadium. San Francisco is a 5.5-point favorite in the contest. The over/under is set at 46 points for the outing.
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How to watch 49ers vs. Colts: TV channel & live stream
TV channel: ESPN
49ers Insights
The 49ers’ offen...
From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| about 1 month ago
| 0 reads
The San Francisco 49ers (10-4) will be monitoring three players on their injury report going into a Monday, Dec. 22 game against the Indianapolis Colts (8-6) at Lucas Oil Stadium, due to start at 8:15 p.m. ET. The Colts currently have five players listed on their report.
How to Watch 49ers vs. Colts
Game date: Monday, December 22, 2025
Time: 8:15 p.m. ET
Venue: Lucas Oil Stadium
Location: Indianapolis, Indiana
TV: ESPN
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From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| about 1 month ago
| 0 reads
The Indianapolis Colts (8-6) will have their eyes set on rebounding from their four-game losing streak when they take on the San Francisco 49ers (10-4) at Lucas Oil Stadium on Monday, December 22, 2025.
49ers vs. Colts Odds
Point Spread
The spread for this matchup is set at 5.5 points, with sportsbooks listing the 49ers as the favorites.
Moneyline
As for the moneyline, the 49ers have -258 odds to pick up the win, while the Colts are listed at +209 to claim victory.
Over/Under
Fin...
From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| about 1 month ago
| 0 reads
San Francisco 49ers tight end Jake Tonges will match up with the 31st-ranked passing defense of the Indianapolis Colts (247.6 yards allowed per game) in Week 16, at 8:15 p.m. ET on Monday.
With his upcoming matchup against the Colts this week, should Tonges be considered a lock for your fantasy football lineup? We dissect the stats and trends below.
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Jake Tonges Week 16 Game Info
Let’s highlight a few of the...
From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| about 1 month ago
| 0 reads
San Francisco 49ers RB Brian Robinson Jr. will take on the fifth-ranked rushing defense of the Indianapolis Colts (95.1 yards conceded per game) in Week 16, at 8:15 p.m. ET on Monday.
Is Robinson worth starting in fantasy this week? Keep scrolling as we dig into his upcoming matchup against the Colts.
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Brian Robinson Jr. Week 16 Game Info
Let’s go into some of the upcoming game’s key info, including the proj...
From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| about 1 month ago
| 0 reads
Kendrick Bourne and the San Francisco 49ers will play the Indianapolis Colts and their 31st-ranked passing defense (247.6 yards conceded per game) in Week 16, on Monday at 8:15 p.m. ET.
With his upcoming game versus the Colts this week, should Bourne be considered a lock for your fantasy football lineup? We dissect the stats and trends below.
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Kendrick Bourne Week 16 Game Info
Let’s highlight a few of the up...
From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| about 1 month ago
| 0 reads
In Week 16 (Monday at 8:15 p.m. ET), wide receiver Demarcus Robinson and the San Francisco 49ers will meet the Indianapolis Colts, who have the 31st-ranked passing defense in the NFL (247.6 yards allowed per game).
Is Robinson’s game against the Colts this week a good time to start him in fantasy? Below, we highlight his relevant fantasy statistics.
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Demarcus Robinson Week 16 Game Info
Let’s go into a few of...
From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| about 1 month ago
| 0 reads
Happy NFL Sunday, Seattle Seahawks fans! There’s really nothing of consequence on the Sunday slate for the Seahawks as it relates to the NFC’s top seed chase. The San Francisco 49ers don’t play until Monday night, the Chicago Bears and Green Bay Packers did sort out the NFC North lead and therefore stay alive for […]
From Field Gulls
| about 1 month ago
| 2 reads
The San Francisco 49ers are inching closer and closer to a playoff berth, getting the chance to clinch their spot in the postseason with a win over the Indianapolis Colts on Monday Night Football in Week 16. To do so, they’ll have to get through Jonathan Taylor, who has been the NFL’s best running back […]
From Niners Nation
| about 1 month ago
| 1 read
The Carolina Panthers loss to the New Orleans Saints in Week 15 technically narrowed their path to the playoffs, but the reality is that still have the same shot they had last week at the division title. Yes, they have been eliminated from wildcard contention, but that effectively happened when they lost to the 49ers […]
From Cat Scratch Reader
| about 1 month ago
| 1 read
49ers’ Ricky Pearsall out for Monday’s game at Colts with knee injury (paywall)“Kyle Shanahan said Pearsall came close to playing versus the Colts. But he didn’t practice this week and was limited to sprinting on a side field during Friday’s session. “He was close, but not close enough,” Shanahan said.“ 49ers vs. Colts: The Standard’s […]
From Niners Nation
| about 1 month ago
| 3 reads
In Week 16 (Monday at 8:15 p.m. ET), wideout Josh Downs and the Indianapolis Colts will face the San Francisco 49ers, who have the 22nd-ranked pass defense in the NFL (227.6 yards conceded per game).
Is Downs’ game against the 49ers this week a good time to start him in fantasy? Below, we break down his relevant fantasy statistics.
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Josh Downs Week 16 Game Info
Let’s go into a few of the upcoming game’s key ...
From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| about 1 month ago
| 4 reads
The San Francisco 49ers (10-4) will visit the Indianapolis Colts (8-6) on Monday at 8:15 p.m. ET. Keep scrolling for DFS analysis.
49ers vs. Colts Game Info
When: Monday, December 22, 2025 at 8:15 p.m. ET
Where: Lucas Oil Stadium in Indianapolis, Indiana
TV info: ESPN
Live Stream: Watch this game on Fubo (Regional restrictions apply)
49ers DFS Projections
Salary values from DraftKings.
Player
Position
Salary
Projected Points
Projected Points per 1K
...
From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| about 1 month ago
| 1 read
The Indianapolis Colts today released their Saturday injury report for Week 16 of the NFL season against the San Francisco 49ers for Monday night. Defensive tackle Deforest Buckner has been listed as QUESTIONABLE for Monday’s games against the 49ers with a neck injury. Buckner looks set to return from injured reserve this week and provide […]
From Stampede Blue
| about 1 month ago
| 1 read
The San Francisco 49ers placed linebacker Nick Martin on the Injured Reserve. He’s been out since he suffered a concussion in Week 15. After being limited this week during practice, it’s likely the 49ers activate defensive lineman Yetur Gross-Matos from the Injured Reserve as the corresponding move. Ricky Pearsall didn’t practice for the third straight […]
From Niners Nation
| about 1 month ago
| 1 read
The San Francisco 49ers are back in primetime in Week 16, taking on the Indianapolis Colts on the road on Monday Night Football. After the Seattle Seahawks won against the Los Angeles Rams in a thriller on Thursday night, the path to the No. 1 seed cleared up for San Francisco: win out and get […]
From Niners Nation
| about 1 month ago
| 1 read
The Indianapolis Colts ruled out cornerback Sauce Gardner ahead of Monday Night Football. It’s not often that the San Francisco 49ers catch an injury break, but this is one of them. Former Niner and All-Pro cornerback Charvarius Ward was placed on the Injured Reserve on December 10 after his third concussion of the season. Gardner […]
From Niners Nation
| about 1 month ago
| 0 reads
The 49ers have voided Brandon Aiyuk’s guaranteed money. A decision made after he stopped coming to the facility, communicating with the team, and long after the team had already lost several contributors in 2025 free agency. By the time all of that happened, the 49ers weren’t just losing players — they were losing margin for […]
From Niners Nation
| about 1 month ago
| 1 read
Yeah, it’s back. Chill out. Listen, I’ve been on the road with this column for over six years. I needed a break and, honestly, I wouldn’t have brought it back if at least one person hadn’t messaged and said: “Where’s the column gone Ben?” So here we are, the first one since the Dons cup […]
From The Tilehurst End
| about 1 month ago
| 1 read
Saleh, Kubiak, Purdy preview 49ers-Colts Week 16 matchup“Because the defense is still maturing, do you have to remind them, don’t look ahead? “No. These guys, they go through their process, we’re human. I can assure you that a lot of the guys were watching the game last night. We’d be lying if we said we […]
From Niners Nation
| about 1 month ago
| 1 read